“I Love You, Man” is my favorite movie. If I had a bad day at work, I’ll throw it on as soon as I get home to help me relax. If I’m having a good day, I’ll throw it on to make the day even better. If I need to get work done, I’ll throw it on so that I have some sense of the passage of time. If… you get the picture.
It’s definitely a niche choice. I’m sure that, in the grand scheme of things, it’s probably not the most memorable work in any of its cast members’ filmographies. It’s no “Star Wars” or “Lord of the Rings” either – people don’t go to conventions and scream “SLAP-A DA BASS” to each other (… as far as I know??).